Procaine HCl 51-05-8 

Hydrochloride /Procaine HCl  Cas: 51-05-8 

1 . Product Profile
Product name: Procaine HCl, Hydrochloride
Alias: Procaine hydrochloride; Aminocaine; Anadolor; Atoxicocaine;

Appearance: White crystalline powder
CAS No.: 51-05-8
EINECS: 200-077-2
Molecular formula: C13H21ClN2O2
Molecular weight: 272.77
Assay: 99%
Melting point: 155-156 ° C
Storage: Shading, confined preservation
2 . Application
Procaine hydrochloride is a kind of local anesthetics, for local anesthesia, nerve block etc, can block the conduction of nerve fibers with anesthetic effect, strong function, low toxicity, and no addiction, but the skin, mucous membrane penetration force is weak, not suitable for surface anesthesia, clinically used to infiltration, spine and conduction anesthesia.

3 . COA

Product name

Procaine HCl

Appearance

White crystalline powder

Assay (C13H20N2O2·HCl)

99.0% to 101.0%

99.5%

Melting point

153~158℃

156.5~157.0℃

Heavy metals

≤20ppm

<5ppm

Acidity

≤0.02N NaOH 0.5ml

0.3ml

Chromatographic purity

Secondary spots≤0.5%,sum≤1.0%

Conforms

Loss on drying

≤1.0%

0.06%

Residue on ignition

≤0.15%

0.03%

Bacterial endotoxins

≤0.6EU/mg

<0.6EU/mg

 

Procaine hcl describtion:
Procaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.

White fine needle crystal or crystalline powder at room temperature, no smell, taste slightly bitter and Ma, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Procaine hydrochloride ester bond structure can be hydrolyzed to produce amino acid and diethylaminoethanol, under certain conditions, the amino acid may be further decarboxylated toxic aniline.

The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0 ~ 5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ºC steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.

The product structure of aromatic primary amino group in dilute hydrochloric acid can generate diazonium salt with sodium nitrite, coupling reaction occurs when add alkaline β- naphthol, generating azo compounds scarlet.

Function Of Procaine HCL
A local anesthetic of the amino ester group that is primarily used as a topical anesthetic.Also used to control the pain of intramuscular injection of penicillin as well as in dentistry.Non Caine local anesthetic.
Procaine hydrochloride is a kind of local anesthetics, for local anesthesia, nerve block etc, can block the conduction of nerve fibers with anesthetic effect, strong function, low toxicity, and no addiction, but the skin, mucous membrane penetration force is weak, not suitable for surface anesthesia, clinically used to infiltration, spine and conduction anesthesia.

 


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